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GUgus_massa45분 전
Previus discussion (from the university press release) https://news.ycombinator.com/item?id=46306894 (498 points | 6 months ago | 140 comments) I'll rehash my comment
They used mice, because they are good for early tries. The researchers had 9 bacterias and only 1 was successful. Experiments in mice are cheaper and have less ethical problems than experiments in humans. (Hey! They even injected the cancer cells in mice and waited a week until it grow. Nobody will approve something like that in humans.)
The title claims that the tumos were eradicated. The title hides that it was a small tumor they injected in the mice and more importantly that it disappeared for two weeks until the experiment ended. It's difficult to guess if it will be useful for humans with bigger tumors because they are harder to detect, and it would work for a interesting enough period like 5 years.
There is also and old comment by octaane https://news.ycombinator.com/item?id=46308732 I'll quote it partially:
> Several things trigger my bullshit meter. Quote:
>> "This dramatically surpasses the therapeutic efficacy of current standard treatments, including immune checkpoint inhibitors (anti-PD-L1 antibody) and liposomal doxorubicin (chemotherapy agents)"
> PD-L1 monoclonal antibodies are only effective against cancers that are PD-L1 positive. [...] Many tumor types are not PD-l1 positive.
> Doxy is an ancient SOC chemo.
> [...]
FRfrellus23분 전
I kid you not, there was a movie with Sean Connery called "Medicine Man" (1992) with this exact same theme.
https://www.imdb.com/title/tt0104839/?ref_=fn_t_1
In it, Connery finds what looks to be a rare natural cure to all cancer in the Rain Forest (spoiler: not a frog, but equally as weird), and is literally battling the nearby deforesting and bulldozers. For a Sean Connery movie it was bizarre (As a young teen, I saw it in the theaters.. quite a bit less action than a 007 movie but good drama and dramatic Sean Connery acting).
GEGeee8분 전
Very cool research. They just injected mice with 45 different bacterial strains, and then isolated and cultivated the ones that had the best performance. It seems that it might be quite easy to cultivate these strains to target different tumors / specific tumor samples.
Full article: https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2...
TItiffanyh1시간 전
To give more credit to this blog post, the NIH published findings on this same subject last year.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12710904/
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Previus discussion (from the university press release) https://news.ycombinator.com/item?id=46306894 (498 points | 6 months ago | 140 comments) I'll rehash my comment They used mice, because they are good for early tries. The researchers had 9 bacterias and only 1 was successful. Experiments in mice are cheaper and have less ethical problems than experiments in humans. (Hey! They even injected the cancer cells in mice and waited a week until it grow. Nobody will approve something like that in humans.) The title claims that the tumos were eradicated. The title hides that it was a small tumor they injected in the mice and more importantly that it disappeared for two weeks until the experiment ended. It's difficult to guess if it will be useful for humans with bigger tumors because they are harder to detect, and it would work for a interesting enough period like 5 years. There is also and old comment by octaane https://news.ycombinator.com/item?id=46308732 I'll quote it partially: > Several things trigger my bullshit meter. Quote: >> "This dramatically surpasses the therapeutic efficacy of current standard treatments, including immune checkpoint inhibitors (anti-PD-L1 antibody) and liposomal doxorubicin (chemotherapy agents)" > PD-L1 monoclonal antibodies are only effective against cancers that are PD-L1 positive. [...] Many tumor types are not PD-l1 positive. > Doxy is an ancient SOC chemo. > [...]
I kid you not, there was a movie with Sean Connery called "Medicine Man" (1992) with this exact same theme. https://www.imdb.com/title/tt0104839/?ref_=fn_t_1 In it, Connery finds what looks to be a rare natural cure to all cancer in the Rain Forest (spoiler: not a frog, but equally as weird), and is literally battling the nearby deforesting and bulldozers. For a Sean Connery movie it was bizarre (As a young teen, I saw it in the theaters.. quite a bit less action than a 007 movie but good drama and dramatic Sean Connery acting).
Very cool research. They just injected mice with 45 different bacterial strains, and then isolated and cultivated the ones that had the best performance. It seems that it might be quite easy to cultivate these strains to target different tumors / specific tumor samples. Full article: https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2...
To give more credit to this blog post, the NIH published findings on this same subject last year. https://pmc.ncbi.nlm.nih.gov/articles/PMC12710904/
Mice are having a great year